Background.The stress response to laryngoscopy and intubation causes an undesirable increase in heart rate, blood pressure, and\r\nintraocular pressure. This study was designed to compare the effect of two doses of gabapentin on the stress response to laryngoscopy\r\nand intubation. Patients andMethods. (ASA I and II) 60 patients, aged from18 to 60 years undergoing elective eye surgery requiring\r\nendotracheal intubation, were randomly allocated into 3 groups, 20 patients each. 2 hours before the surgery, group I received oral\r\nplacebo, and groups II and III received oral gabapentin 800mg and 1200mg, respectively. Heart rate (HR), mean arterial pressure\r\n(MAP), and intraocular pressure (IOP) were measured before and after induction of anesthesia, immediately after, 5 minutes, and\r\n10 minutes after intubation. Results. Gabapentin 1200mg prevented the increase in HR, MAP, and IOP, secondary to laryngoscopy\r\nand intubation, and kept them below the baseline till 10 minutes after intubation (?? < 0.001), while with gabapentin 800mg, the\r\nincrease in HR, MAP, and IOP was nonsignificant (?? > 0.05) and returned to levels below the baseline at 5 and 10 minutes after\r\nintubation. Conclusion. Preoperative gabapentin 1200mg effectively prevented the stress response to laryngoscopy and intubation;\r\nmeanwhile, gabapentin 800mg only prevented significant stress response.
Loading....